AWS IMAGINE Grant Propels EGPAF’s AI-Powered Pediatric HIV Care

In late 2024, the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF) was honored as one of the inaugural winners of the Amazon Web Services (AWS) IMAGINE Grant: Children’s Health Innovation Award. This new funding stream—designed to accelerate breakthroughs in children’s health through advanced cloud services like generative AI—recognized EGPAF’s bold vision to harness data and machine learning for improved HIV care outcomes across Africa.

Bringing Real-Time Risk Insights to Clinicians

With the AWS IMAGINE Grant’s combination of financial support, cloud credits, and expert mentorship, EGPAF is building an integrated platform that plugs directly into existing EMR and national data repositories in Kenya, Malawi, and Zimbabwe. By layering generative AI models atop these rich data sources, our solution continuously analyzes patient records to:

• Flag treatment-failure risks before they emerge
• Predict loss to follow-up and recommend timely outreach
• Generate personalized care prompts for clinicians at the point of service

This shift from retrospective reporting to real-time proactive insights empowers healthcare providers to tailor interventions, optimize resource use, and keep children living with HIV on the path to viral suppression.

Co-Creating with Country Partners

EGPAF’s success hinges on true collaboration. From the earliest design sprints through each deployment phase, we work side-by-side with ministries of health, hospital leadership, and frontline clinicians to:

• Define locally relevant risk factors and outcome measures
• Adapt AI workflows to fit existing care pathways and IT infrastructure
• Build training modules that ensure rapid uptake and sustainable use

This co-creation model not only drives higher adoption but also strengthens local data governance and analytics capacity—laying the foundation for future digital health innovations.

A Recognition of Innovation and Impact

The Children’s Health Innovation Award spotlights projects that marry cutting-edge cloud technology with mission-critical goals. EGPAF’s proposal was selected for its:

1. Originality: Pioneering use of generative AI within pediatric HIV care
2. Impact Potential: Clear pathways to improve adherence and retention metrics
3. Measurable Milestones: Predefined benchmarks for risk-flag accuracy, intervention timeliness, and viral suppression rates

“We are thrilled to announce this inaugural cohort of recipients pursuing groundbreaking advancements in children’s health,” said Dave Levy, Head of Worldwide Public Sector at AWS. “These teams have audacious plans to improve outcomes at scale, and we look forward to making them a reality with cloud technology.”

Accelerating Toward Ending Pediatric AIDS by 2030

“EGPAF has always prioritized leveraging new technologies toward our mission of ending the pediatric AIDS epidemic,” said Trish Karlin, Executive Vice President of External Affairs and Business Development at EGPAF. “Through the AWS IMAGINE Grant, we’ll deepen our life-saving work—cultivating equitable health systems and ensuring that no child is ever devastated by HIV/AIDS.”

As we move through 2025, EGPAF is expanding our AI-driven platform to include mobile outreach alerts, interactive country-level dashboards, and open-source toolkits for partner countries. Together with AWS and our local collaborators, we are turning data into action—and accelerating progress toward epidemic control and a world free of pediatric AIDS.

Over 85,000 nonprofits worldwide leverage AWS to scale impact, break through technical barriers, and drive mission success. EGPAF’s award highlights the transformative power of cloud-enabled innovation in children’s health.